Acetazolamide is a diuretic that blocks the activity of the enzyme carbonic anhydrase inside kidney tubule cells. This blockage prevents the
formation of carbonic acid from CO2 and water. Normally, carbonic
acid dissociates to form H+ and HCO3
−, and the H+ is exchanged for
Na+ from the urine. Blocking the formation of H+ in the tubule cells
blocks Na+ reabsorption, thus inhibiting water reabsorption and
producing the diuretic effect. With this information in mind, what effect
does acetazolamide have on blood pH, urine pH, and respiratory rate?
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