Phenylephrine is a nasal decongestant and is the active ingredient in Sudafed, which contains phenylephrine hydrochloride (PEHCl)
A) In pharmaceuticals, it is common to coordinate bioactive molecules with either an acid or a base. Here, PE is coordinated with the acid HCl. Draw the structure of PEHCl, being explicit to show which atom in PE accepts the H+ from HCl.
B) If the pKa of PEHCl is 5.5, where is PE absorbed: the stomach (pH ≈ 2) or the small intestine (pH ≈ 8)? Provide a brief explanation to support your answer.
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